Tirzepatide
Compounded tirzepatide with B6, the same active ingredient as Mounjaro® and Zepbound®. One vial is one month.
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About this treatment
Less hunger. More support for your weight goals.
Tirzepatide can reduce hunger, help you feel fuller and make cravings easier to manage. Those changes can support the eating and activity plan you build with your IAM care team.
Help hunger take up less of your day
In a randomized study, tirzepatide reduced perceived hunger, food cravings and the tendency to overeat. Having less appetite-driven pressure can make it easier to work with an eating plan that suits your daily life.
Feel satisfied with less food
Tirzepatide can increase fullness and reduce food intake. Feeling satisfied with smaller portions can help you make eating changes while keeping regular meals and adequate nutrition part of your plan.
Support meaningful weight progress
In SURMOUNT-1, adults taking tirzepatide lost an average of 15.0% to 20.9% of their starting body weight over 72 weeks, depending on the study dose, alongside changes to eating and activity. Your care team follows your response and helps you work toward your own weight and health goals.
Two signals involved in appetite
Tirzepatide activates GIP and GLP-1 receptors, which are involved in appetite and blood-sugar regulation. These food-related hormone pathways help explain how the medicine reduces appetite and energy intake.
Plan for progress that lasts
Continued treatment helped people maintain and build on their weight loss in SURMOUNT-4. Follow-up gives you and your provider time to review how treatment feels, adjust your care and plan for weight maintenance as you approach your goal.
Research and product information
The appetite studies used specific tirzepatide formulations. SURMOUNT-1 studied adults with obesity, or overweight with a weight-related condition, without diabetes. IAM offers compounded tirzepatide with B6, which is not FDA-approved; these studies did not test IAM's formulation.
- Randomized tirzepatide study: hunger, fullness, cravings and food intake
- Zepbound: prescribing information and weight-management studies
- SURMOUNT-1: tirzepatide once weekly for treatment of obesity
- SURMOUNT-4: continued tirzepatide and weight maintenance
- FDA: information about compounded GLP-1 medicines
Sources checked .
What's in each plan
Tirzepatide vial
- Tirzepatide/B6 20mg/25mg, 2mL vial
- Syringes and alcohol swabs
- Free video consult and follow-up
- Patient portal messaging
What's included in every program
Provider review
A free video visit with a licensed provider, who reviews your history and labs before anything is prescribed.
Medication and supplies
Your medication plus syringes, alcohol pads and a mixing kit when one is needed. No pharmacy runs.
Ongoing support
Message your care team through the portal whenever you have a question about your plan.
Before you start
Who should not take this
Do not take this medicine if you or anyone in your family has had medullary thyroid cancer, or multiple endocrine neoplasia type 2 (MEN2). In animal studies this class of medicine caused thyroid tumours. Whether it does the same in people is not known, which is why the approved versions of it carry a boxed warning, and why we ask before prescribing.
Also tell us before you start if you have ever had pancreatitis; are pregnant, breastfeeding or planning a pregnancy; have had a severe allergic reaction to a GLP-1 medicine; take insulin or a sulfonylurea for diabetes; have kidney problems or a history of diabetic retinopathy; or have gastroparesis.
What to expect
Most people feel some nausea, and often constipation or diarrhoea, strongest in the first weeks and after each dose increase. It usually settles. The dose is stepped up slowly for exactly this reason, and going slower is always an option.
Reduced appetite can make it harder to eat enough. Discuss adequate nutrition, protein and resistance exercise with your care team to support muscle health. Vomiting or diarrhea can cause dehydration and kidney problems. Keep up fluids as your health allows, and contact your care team if you cannot keep fluids down.
Tell us straight away if
You get severe stomach pain that does not go away, especially with vomiting. This can be pancreatitis and needs looking at the same day.
You find a lump in your neck, become hoarse or have trouble swallowing; you have pain under your right ribs, fever, or yellowing of the skin or eyes; or you cannot keep fluids down.
Trouble breathing or swelling of the face or throat needs emergency care.
Pregnancy and oral contraception
If you become pregnant while using tirzepatide for weight management, stop treatment and contact your prescriber.
Tirzepatide can reduce the effectiveness of oral hormonal contraception. The approved label advises switching to a non-oral method or adding a barrier method for four weeks after starting treatment and for four weeks after each dose increase. Discuss your contraception plan with your prescribing team.
Before any surgery or procedure with sedation
Tell the anesthesia and procedure teams that you take a GLP-1 medicine, including before an endoscopy or dental procedure with sedation. Slower stomach emptying can raise aspiration risk. Many patients can continue treatment, while others need an adjusted plan based on symptoms and procedure risk. Ask the team planning your procedure for instructions instead of holding or restarting doses on your own.
If you use oral contraception
Tirzepatide can make birth-control pills less reliable, because of the way it slows the stomach. For four weeks after you start, and for four weeks after every dose increase, either switch to a non-oral method or add a barrier method.
