Treatment for Low T: Testosterone Replacement Therapy Explained

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Millions of men are on testosterone replacement therapy to restore their vitality, increase their muscle mass, improve their mood and increase their sex drive. But unfortunately, doctors have misdiagnosed many of these men for years by assuming that the myriad of problems, such as depression, anxiety, fatigue, erectile dysfunction, and loss of libido, were either typical for them or a sign of aging.

What is Testosterone Replacement Therapy (TRT)?

Testosterone Replacement Therapy (TRT) is a treatment option for men experiencing symptoms related to low testosterone levels. Testosterone plays a crucial role in the development of masculine characteristics, as well as overall physical and emotional well-being. While a decline in testosterone levels is common with aging, low testosterone can also occur in men of any age due to conditions such as hypogonadism.

This idea that we should not meddle with mother nature is hogwash. We meddle with nature every day when it comes to our health.

Normal, natural aging is associated with bad eyes, hearing, teeth, joints, blood vessels, heart, and cancer. We treat all these to improve quality of life or increase longevity.

Should we withhold offering prescription glasses to older men and women because poor vision is common with advancing years and, thus, normal? It’s a ridiculous notion.

Low testosterone is no different just because low testosterone becomes more common as men age is no reason we should deny treatment.

Dr. Morgentaler, an internationally recognized expert in sexual medicine and male hormones

Symptoms of Low Testosterone

Low levels of testosterone can lead to a host of debilitating symptoms, including:

  1. A constant state of fatigue leaves you feeling drained and unable to keep up with daily activities
  2. A lack of interest in sex and difficulty maintaining an erection.
  3. A noticeable muscle mass and strength decrease, making even simple tasks a struggle
  4. A feeling of hopelessness and overwhelming sadness leads to depression
  5. Loss of body hair, hot flashes, and a decrease in bone density

These symptoms can affect not only a man’s physical health but also his emotional and psychological well-being, making it difficult for him to enjoy life fully.

How TRT Works

Treatment for low testosterone levels, or hypogonadism, involves replacing the missing hormone to alleviate symptoms. TRT can take various forms, such as injections, gels, pellets, or patches. However, injections are considered the most reliable and efficient method of TRT. They provide a steady and consistent testosterone level, allowing for effective symptom management.

While alternative forms of TRT, such as gels, pellets, and patches, may offer convenience, they may not be as effective in treating low testosterone symptoms. These methods may not provide a consistent testosterone level, making it harder to manage symptoms. Additionally, they may also cause more side effects compared to injections.

Administration Schedule

The optimal testosterone administration is through a dose-splitting schedule, where the patient receives a lower dose twice a week, for example, on Mondays and Thursdays. This approach helps maintain consistent testosterone levels in the body, effectively alleviating symptoms of low testosterone levels. This modern regimen is considered the most effective way to manage TRT.

On the other hand, administering TRT every 14 days is not recommended as it can lead to a “rollercoaster” effect, where testosterone levels drop back to baseline by the 14th day, directing to a fluctuation of symptoms. This method can also create an uncomfortable feeling of constantly starting and stopping therapy and affect overall health. In addition, it’s a shock to the body.

Intramuscular vs. Subcutaneous Injection

When administering testosterone injections, there are two main methods to choose from: intramuscular and subcutaneous. Both ways are equally effective in delivering testosterone to the body, but the choice often comes down to personal preference.

Intramuscular injections are delivered directly into a muscle, such as the glutes or deltoid muscle. This method tends to have a faster onset of action.

On the other hand, subcutaneous injections are given just under the skin, typically in the abdominal area. This method may have a slower onset of action.

Ultimately, it’s imperative to consult with a prescribing clinician to determine the best method of administration for your individual needs. 

Benefits of TRT

Testosterone can alleviate a wide range of symptoms associated with low testosterone levels, including:

  1. Reviving a low sex drive 
  2. Improving erectile dysfunction 
  3. Increasing muscle mass 
  4. Improving mood and reducing symptoms of depression 
  5. Enhancing the overall quality of life 
  6. Improving bone density 
  7. Lowering the risk of heart disease by improving cholesterol levels
  8. Having a positive impact on cardiovascular health

TRT is a powerful tool for men facing the effects of low testosterone. It can help them regain their vitality, strength, and overall well-being.

Risks and Side Effects

Low testosterone treatment is a safe and effective therapeutic option for men with low testosterone levels. While there may be some potential side effects, current research does not show a link between TRT and prostate cancer.

Some possible side effects of TRT may include the following:

  • Acne
  • Breast enlargement
  • Increased red blood cells
  • However, with close monitoring by a healthcare professional, these side effects can be minimized and controlled

It is important to note that TRT is a personalized treatment plan. Therefore, it is crucial to closely monitor testosterone levels and symptoms while on therapy to ensure optimal results with minimal side effects. TRT can help men regain their vitality, strength, and overall well-being, making it an appealing treatment option for those facing the effects of low testosterone.

Long-Term Testosterone Safety

12-Year Safety of Testosterone Treatment in Hypogonadal Men: A Prospective Controlled Registry Study:

The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study” looks at the safety of testosterone treatment in men with hypogonadism over 12 years. The study found that long-term testosterone treatment in hypogonadal men is safe, with sustainable results, and does not negatively affect endocrine parameters.


The information provided by Illinois Alternative Medicine (IAM) is for general informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

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Eligibility for any treatment and estimated prices may vary depending on individual circumstances, insurance coverage, and applicable laws. All prices and comparisons are estimates, and actual costs may vary. Results may also vary and are not guaranteed.


The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study

Hypogonadism, ADAM, and hormone replacement

Testosterone Therapy and Cardiovascular Risk: Advances and Controversies

Understanding How Testosterone Affects Men

Low serum testosterone and mortality in male veterans

Testosterone and cardiovascular risk

Testosterone and dihydrotestosterone and incident ischaemic stroke in men in the Cardiovascular Health Study

Subcutaneous Administration of Testosterone as an Alternative to Intramuscular Injection

Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients

Updated Review of Testosterone Replacement Therapy in the Setting of Prostate Cancer

Testosterone Therapy in Men with Advanced Prostate Cancer

Influence of demographic factors and biochemical characteristics on the prostate-specific antigen (PSA) response to testosterone replacement therapy

The effect of aging on spermatogenesis and pregnancy outcomes